Positive inotropic activity of derivatives of adenosine cyclic 3’,5’-monophosphate (c AMP)
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چکیده
منابع مشابه
Positive inotropic effects of dibutyryl cyclic adenosine 3',5'-monophosphate.
The positive inotropic effects of catecholamines have been postulated to result from an increase in the intracellular level of cyclic AMP (adenosine 3',5'-monophosphate) produced by activation of adenyl cyclase. Although lack of an inotropic effect by exogenously administered cyclic AMP has cast doubt on this hypothesis, cardiac cells are not readily permeable to cyclic AMP. The N-2'-O-dibutyry...
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The effects of natural cyclodepsipeptides (CDPs) on isolated rat cardiac tissue preparations were examined in vitro. Destruxin A, destruxin B (DB), roseotoxin B (RB), and roseocardin (RC), a novel CDP, each caused a concentration-dependent increase in the contraction force of the right atrium and the papillary and trabecular muscles of the right ventricle at 0.6 to 600 microM. RB, destruxin A, ...
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An abstract ofthis work appeared in 1976. Clin. Res. 24: 456A. (Abstr.) Dr. Broadus' present address is Division of Endocrinology, Department of Internal Medicine, Yale University, New Haven, Conn. 06510. Received for publication 20 April 1976 and in revisedform 13 June 1977. the validity of the measurements and the expressions employed.
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When the content of cyclic AMP (cAMP) was compared in livers of a series of congenic mouse strains differing at the H-2 locus, significant variation in concentration of cAMP per unit wet weight was found among strains, and also for animals of a given strain with increasing age. For a given age, from 8 to 22 weeks, cAMP levels in liver of H-2a and H-2b genotype animals were significantly higher ...
متن کاملRenal Effects of Adenosine 3 ' , 5 ' - Cyclic Monophosphate and Dibutyryl Adenosine 3 , 5 ' - Cyclic Monophosphate
An abstract of this work appeared in 1970 Abstracts, The American Society of Nephrology. Received for publication 27 October 1970 and in revised form 28 January 1971. similar to the effect of renal arterial infusion of isoproterenol. The results suggest that synthesis of cyclic AMP in proximal renal tubule cells in response to stimulation of beta adrenergic or other receptors can mediate a decr...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1984
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)62255-9